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Compound Profiling
Pharmacology profiling is an invaluable tool for lead compound screening, optimization and candidate prioritization. Analysis of compound profile data identifies off-target interactions that can help predict potential side-effects and safety issues of compounds under development before they progress to the more costly stages of preclinical and clinical trials. HDB offers comprehensive profiling services to meet our clients' drug
discovery & development needs.
Our compound profiling service include:
GPCRs
Panels of 20, 30, 60 GPCRs for selectivity screening
Cell-based functional assays, membrane prep binding assays or GTPγS binding assays
Enzymes
Kinase selectivity (panels of 20-, 40-, 60-kinases )
Enzyme assays or SPA/radiometric assays
ADME
Solubility
Plasma protein binding
Metabolic stability
Permeability (Caco-2)
CYPs inhibition
Human CYP3A4 induction cell based assay
Human CYP1A induction cell based assay
P-gp inhibition cell based assay
In vitro Toxicity
hERG assay (patch-clamp; binding assays)
Ames test, micronucleus test
Hepatotoxicity
Cytotoxic ATP depletion assay
Mitochondria toxicity
Functional Cell-based Assays
High content assays
Phenotypic cellular assays
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
[email protected]
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