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TNBS-IBD
Model: 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced IBD in SJL/J mice
Animal: SJL/J mice
Inducer: TNBS
Study duration: one week (in life)
Pathological features:
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Colon ulceration
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Transmural leukocyte infiltration, distorted crypt and bowel-wall thickning
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CD4-mediated TH1 disease
Suitability:
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Efficay study against crohn's disease
Parameter measures:
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Body weight
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Clinical score (stool consistence, occult bleeding)
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Colon weight/colon length
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Histo-pathology assessment
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IHC
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cytokine (ELISA or RT-qPCR, optional)
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HD Biosciences (China) Co.,Ltd
590 Ruiqing Road
Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
Tel: +86 (21) 5116 3700
Fax: +86 (21) 5116 3766
[email protected]
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