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EAE-cuprizone
Model: Cuprizone induced EAE in SJL/J mice - demyelination model
Animal: SJL/J
Inducer: 0.2% cuprizone in powder ground mouse chow (GMC)
Study duration: 12 weeks (in life)
Pathological features:
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Acute or chronic demyelination in CNS
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Oligodendrocyte damage
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Spontaneous remeylination in acute model
Suitability:
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De-myelination,neuron regeneration and T cell response
Parameter measures:
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Body weight
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Histo-pathological assessment
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IHC
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