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Arthritis (mice)
Model: Collagen type II induced arhtritis in mice (CIA)
Animal: DBA/1
Immunogen: type II collagen (chicken)
Study duration: 8-9 weeks (in life)
Pathological features:
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Slower onset
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Synovitis, pannus formation, cartilage damage and bone erosion
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High levels of anti-CII antibody production
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Mononuclear cell infiltration, synovial hyperplasia and marginal
erosion are similar to AIA and human RA
Suitability:
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Drug development
Parameter measures:
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Body weight
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clinical score
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Hind paw swelling
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X-ray examination
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Histo-pathological examination
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cytokine (optional)
ctrl: normal synovial lining
CIA: Bone/cartilage erosion and inflammatory infiltration
CIA: cellular infiltration in synovial lining
CIA: Muscle damage and synovial hyperplasia
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