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CIA
Model: Collagen type II induced arhtritis in rats (CIA)
Animal: Lewis rat/wistar rats, female,7-9 weeks, 130-150g
Immunogen: type II collagen (bovine)
Study duration: 4 weeks (in life)
Pathological features:
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Marked cartilage destruction, associated with immune complex
deposition on articular surfaces
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Bone resorption and periosteal proliferation, together with
synovitis and periarticular inflammation
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Robust immune response includes CII-specific T and B cells.
Complement dependent
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Inflammatory cell infiltrate predominantly of polymorphonuclear
cells, unlike human disease
Suitability:
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Drug development
Parameter measures:
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Body weight
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clinical score
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Hind paw swelling
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X-ray examination
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Histo-pathological examination
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cytokine (optional)
X-ray examination
naive control
model
Micro-CT analysis on CIA rat
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HD Biosciences (China) Co.,Ltd
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Zhangjiang East Campus, Pudong, Shanghai 201201,
P.R.China
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