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Arthritis (AIA)
Model: Adjuvant induced arthritis in rats (AIA)
Animal: Lewis rat
Immunogen: modified CFA
Study duration: 5 weeks (in life)
Pathological features:
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Marked bone resorption and periosteal bone proliferation
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T cell and neutrophil dependent, complement independent
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Cartilage damage to a lesser degree
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B cell invovlvement is minimal
Suitability:
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COX inhibitor development, general anti-arthritis development
Parameter measures:
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Body weight
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clinical score
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Hind paw swelling
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X-ray examination
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Histo-pathological examination
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